Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II
YC Kudva, G Rajagopalan, R Raju, RS Abraham… - Human immunology, 2002 - Elsevier
To evaluate the contributions of DR3 and DQ8 to the etiopathogenesis of type 1 diabetes in
a diabetes-predisposing milieu, we developed human leukocyte antigen (HLA) transgenic
mice on the nonobese diabetic (NOD) background in the absence of the endogenous class
II molecule, I-Ag7 and studied the incidence of both spontaneous and experimental
(induced) autoimmune diabetes. Transgenic expression of HLA-DR3 and-DQ8 (either alone
or in combination) did not confer susceptibility to spontaneous or cyclophosphamide …
a diabetes-predisposing milieu, we developed human leukocyte antigen (HLA) transgenic
mice on the nonobese diabetic (NOD) background in the absence of the endogenous class
II molecule, I-Ag7 and studied the incidence of both spontaneous and experimental
(induced) autoimmune diabetes. Transgenic expression of HLA-DR3 and-DQ8 (either alone
or in combination) did not confer susceptibility to spontaneous or cyclophosphamide …
