Transformation of polycythemia vera to acute nonlymphocytic leukemia accompanied by t (1; 3)(p36; q21) karyotype
V Najfeld, T Coyle, PD Berk - Cancer genetics and cytogenetics, 1988 - Elsevier
The case of a patient with a history of polycythemia vera and 46, XX karyotype who
transformed into acute nonlymphocytic leukemia with 46, XX, t (1; 3)(p36; q21)
rearrangement is reported. Significant percentages of the circulating blasts in the peripheral
blood were positive on immunocytochemical stains for megakaryocyte markers, anti-Factor
VIII, and antiglycoprotein IIb/IIIa. On the basis of our studies and published reports, trilineage
hematopoietic abnormalities and a poor response to therapy may represent typical features …
transformed into acute nonlymphocytic leukemia with 46, XX, t (1; 3)(p36; q21)
rearrangement is reported. Significant percentages of the circulating blasts in the peripheral
blood were positive on immunocytochemical stains for megakaryocyte markers, anti-Factor
VIII, and antiglycoprotein IIb/IIIa. On the basis of our studies and published reports, trilineage
hematopoietic abnormalities and a poor response to therapy may represent typical features …