Mitochondrial dysfunction in COPD patients with low body mass index
RA Rabinovich, R Bastos, E Ardite… - European …, 2007 - Eur Respiratory Soc
European Respiratory Journal, 2007•Eur Respiratory Soc
Patients with chronic obstructive pulmonary disease (COPD) show abnormal adaptations of
skeletal muscle redox status after exercise training. Increased skeletal muscle oxidative
stress in COPD patients may prompt mitochondrial dysfunction. The present study explores
the association between body composition and mitochondrial respiration in seven COPD
patients with low body mass index (BMIL), eight COPD patients with normal body mass
index (BMIN) and seven healthy controls. All of them underwent a vastus lateralis biopsy in …
skeletal muscle redox status after exercise training. Increased skeletal muscle oxidative
stress in COPD patients may prompt mitochondrial dysfunction. The present study explores
the association between body composition and mitochondrial respiration in seven COPD
patients with low body mass index (BMIL), eight COPD patients with normal body mass
index (BMIN) and seven healthy controls. All of them underwent a vastus lateralis biopsy in …
Patients with chronic obstructive pulmonary disease (COPD) show abnormal adaptations of skeletal muscle redox status after exercise training. Increased skeletal muscle oxidative stress in COPD patients may prompt mitochondrial dysfunction.
The present study explores the association between body composition and mitochondrial respiration in seven COPD patients with low body mass index (BMIL), eight COPD patients with normal body mass index (BMIN) and seven healthy controls. All of them underwent a vastus lateralis biopsy in which muscle structure, in vitro mitochondrial respiratory function, uncoupling protein 3 (UCP3) mRNA expression and glutathione levels in both isolated mitochondria and the whole muscle were determined.
Mitochondrial respiratory function (assessed by acceptor control ratio (ACR)) was impaired in BMIL (2.2±0.6) compared with both BMIN (5.3±1.3) and controls (8.2±1.3). ACR significantly correlated with arterial oxygen tension and with muscle endurance but it showed a negative association with exercise-induced increase in blood lactate levels. UCP3 mRNA expression was reduced in BMIL patients.
In conclusion, chronic obstructive pulmonary disease patients with low body mass index show electron transport chain dysfunction, which may contribute to low muscle endurance in the current subgroup of patients.
European Respiratory Society