[HTML][HTML] TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular …
A Liu, P Gong, SW Hyun, KZQ Wang, EA Cates… - Journal of Biological …, 2012 - ASBMB
Gram-negative bacteria release lipopolysaccharide (LPS) into the bloodstream. Here, it
engages Toll-like receptor (TLR) 4 expressed in human lung microvascular endothelia
(HMVEC-Ls) to open the paracellular pathway through Src family kinase (SFK) activation.
The signaling molecules that couple TLR4 to the SFK-driven barrier disruption are unknown.
In HMVEC-Ls, siRNA-induced silencing of TIRAP/Mal and overexpression of dominant-
negative TIRAP/Mal each blocked LPS-induced SFK activation and increases in …
engages Toll-like receptor (TLR) 4 expressed in human lung microvascular endothelia
(HMVEC-Ls) to open the paracellular pathway through Src family kinase (SFK) activation.
The signaling molecules that couple TLR4 to the SFK-driven barrier disruption are unknown.
In HMVEC-Ls, siRNA-induced silencing of TIRAP/Mal and overexpression of dominant-
negative TIRAP/Mal each blocked LPS-induced SFK activation and increases in …