Wnt and calcium signaling: β-catenin-independent pathways
AD Kohn, RT Moon - Cell calcium, 2005 - Elsevier
Wnt signaling is a complex pathway in which β-catenin is typically viewed as a central
mediator. However, within the past 15 years, at least three Wnt-mediated pathways have
been proposed that function independent of β-catenin. One pathway involves activation of
calcium/calmodulin-dependent kinase II (CamKII) and protein kinase C (PKC). Another
includes recruitment of heterotrimeric GTP-binding proteins to activate phospholipase C
(PLC) and phosphodiesterase (PDE). Lastly, a pathway similar to the planar cell polarity …
mediator. However, within the past 15 years, at least three Wnt-mediated pathways have
been proposed that function independent of β-catenin. One pathway involves activation of
calcium/calmodulin-dependent kinase II (CamKII) and protein kinase C (PKC). Another
includes recruitment of heterotrimeric GTP-binding proteins to activate phospholipase C
(PLC) and phosphodiesterase (PDE). Lastly, a pathway similar to the planar cell polarity …
