Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
MJ Potthoff, SA Kliewer… - Genes & …, 2012 - genesdev.cshlp.org
MJ Potthoff, SA Kliewer, DJ Mangelsdorf
Genes & development, 2012•genesdev.cshlp.orgWe review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)—
FGF15/19 and FGF21—that can function as hormones. Both FGF15/19 and FGF21 act on
multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional
status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and
has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and
has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues …
FGF15/19 and FGF21—that can function as hormones. Both FGF15/19 and FGF21 act on
multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional
status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and
has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and
has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues …
We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)—FGF15/19 and FGF21—that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.
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