Identification of a novel FGF, FGF-21, preferentially expressed in the liver
T Nishimura, Y Nakatake, M Konishi, N Itoh - Biochimica et Biophysica Acta …, 2000 - Elsevier
We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is
the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino
terminus (∼ 30 amino acids), which is a typical signal sequence, and appears to be a
secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by
Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and
also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF …
the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino
terminus (∼ 30 amino acids), which is a typical signal sequence, and appears to be a
secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by
Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and
also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF …
