[HTML][HTML] GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association
GE Cozier, PJ Lockyer, JS Reynolds, S Kupzig… - Journal of Biological …, 2000 - ASBMB
The group I family of pleckstrin homology (PH) domains are characterized by their inherent
ability to specifically bind phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P 3) and
its corresponding inositol head-group inositol 1, 3, 4, 5-tetrakisphosphate (Ins (1, 3, 4, 5) P
4). In vivo this interaction results in the regulated plasma membrane recruitment of cytosolic
group I PH domain-containing proteins following agonist-stimulated PtdIns (3, 4, 5) P 3
production. Among group I PH domain-containing proteins, the Ras GTPase-activating …
ability to specifically bind phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P 3) and
its corresponding inositol head-group inositol 1, 3, 4, 5-tetrakisphosphate (Ins (1, 3, 4, 5) P
4). In vivo this interaction results in the regulated plasma membrane recruitment of cytosolic
group I PH domain-containing proteins following agonist-stimulated PtdIns (3, 4, 5) P 3
production. Among group I PH domain-containing proteins, the Ras GTPase-activating …