[HTML][HTML] Thioredoxin and thioredoxin reductase control tissue factor activity by thiol redox-dependent mechanism
P Wang, Y Wu, X Li, X Ma, L Zhong - Journal of Biological Chemistry, 2013 - ASBMB
Abnormally enhanced tissue factor (TF) activity is related to increased thrombosis risk in
which oxidative stress plays a critical role. Human cytosolic thioredoxin (hTrx1) and
thioredoxin reductase (TrxR), also secreted into circulation, have the power to protect
against oxidative stress. However, the relationship between hTrx1/TrxR and TF remains
unknown. Here we show reversible association of hTrx1 with TF in human serum and
plasma samples. The association is dependent on hTrx1-Cys-73 that bridges TF-Cys-209 …
which oxidative stress plays a critical role. Human cytosolic thioredoxin (hTrx1) and
thioredoxin reductase (TrxR), also secreted into circulation, have the power to protect
against oxidative stress. However, the relationship between hTrx1/TrxR and TF remains
unknown. Here we show reversible association of hTrx1 with TF in human serum and
plasma samples. The association is dependent on hTrx1-Cys-73 that bridges TF-Cys-209 …