[HTML][HTML] Fibrinogen and von Willebrand factor‐independent platelet aggregation in vitro and in vivo
H Yang, A Reheman, P Chen, G Zhu, RO Hynes… - Journal of Thrombosis …, 2006 - Elsevier
Summary Background: Fibrinogen (Fg) has been considered essential for platelet
aggregation. However, we recently demonstrated formation of occlusive thrombi in Fg‐
deficient mice and in mice doubly deficient for Fg and von Willebrand factor (Fg/VWF−/−).
Methods and results: Here we studied Fg/VWF‐independent platelet aggregation in vitro
and found no aggregation in citrated platelet‐rich plasma of Fg/VWF−/− mice. Surprisingly,
in Fg/VWF−/− plasma without anticoagulant, adenosine diphosphate induced robust …
aggregation. However, we recently demonstrated formation of occlusive thrombi in Fg‐
deficient mice and in mice doubly deficient for Fg and von Willebrand factor (Fg/VWF−/−).
Methods and results: Here we studied Fg/VWF‐independent platelet aggregation in vitro
and found no aggregation in citrated platelet‐rich plasma of Fg/VWF−/− mice. Surprisingly,
in Fg/VWF−/− plasma without anticoagulant, adenosine diphosphate induced robust …