[HTML][HTML] αvβ3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
SD Robinson, LE Reynolds, V Kostourou… - Journal of biological …, 2009 - ASBMB
Both vascular endothelial growth factor receptors (VEGFR) and integrins are major
regulators of VEGF-induced angiogenesis. Previous work has shown that β3 integrin can
regulate negatively VEGFR2 expression. Here we show that β3 integrin can regulate
negatively VEGF-mediated angiogenesis by limiting the interaction of the co-receptor NRP1
(neuropilin-1) with VEGFR2. In the presence of αvβ3 integrin, NRP1 contributed minimally to
VEGF-induced angiogenic processes in vivo, ex vivo, and in vitro. Conversely, when β3 …
regulators of VEGF-induced angiogenesis. Previous work has shown that β3 integrin can
regulate negatively VEGFR2 expression. Here we show that β3 integrin can regulate
negatively VEGF-mediated angiogenesis by limiting the interaction of the co-receptor NRP1
(neuropilin-1) with VEGFR2. In the presence of αvβ3 integrin, NRP1 contributed minimally to
VEGF-induced angiogenic processes in vivo, ex vivo, and in vitro. Conversely, when β3 …