Notch is a transmembrane receptor that controls a diverse array of cellular processes
including cell proliferation, differentiation, survival, and migration. The cellular outcome of
Notch signaling is dependent on extracellular and intracellular signals, but the complexities
of its regulation are not well understood. Canonical Notch signaling involves ligand
association that triggers sequential and regulated proteolysis of Notch at several sites.
Ligand-dependent proteolysis at the S2 site removes the bulk of the extracellular domain of …