Free fatty acids and insulin resistance
The increase in free fatty acid flux resulting from increased lipolysis secondary to adipose-
tissue insulin resistance induces or aggravates insulin resistance in liver and muscle
through direct or indirect (from triglyceride deposits) generation of metabolites, altering the
insulin signalling pathway. Alleviating the excess of free fatty acids is a target for the
treatment of insulin resistance.
tissue insulin resistance induces or aggravates insulin resistance in liver and muscle
through direct or indirect (from triglyceride deposits) generation of metabolites, altering the
insulin signalling pathway. Alleviating the excess of free fatty acids is a target for the
treatment of insulin resistance.
Summary
The increase in free fatty acid flux resulting from increased lipolysis secondary to adipose-tissue insulin resistance induces or aggravates insulin resistance in liver and muscle through direct or indirect (from triglyceride deposits) generation of metabolites, altering the insulin signalling pathway. Alleviating the excess of free fatty acids is a target for the treatment of insulin resistance.
Lippincott Williams & Wilkins