Treg cells: patrolling a dangerous neighborhood
DJ Campbell, MA Koch - Nature medicine, 2011 - nature.com
Nature medicine, 2011•nature.com
How B cell tolerance is retained during somatic hypermutation in germinal centers is
incompletely understood. Two studies now show that Foxp3+ regulatory T cells undergo
functional specialization to limit the magnitude of the germinal center response, and they
may contribute to our understanding of how germinal center–mediated autoimmunity is
prevented (pages 975–982 and 983–988).
incompletely understood. Two studies now show that Foxp3+ regulatory T cells undergo
functional specialization to limit the magnitude of the germinal center response, and they
may contribute to our understanding of how germinal center–mediated autoimmunity is
prevented (pages 975–982 and 983–988).
How B cell tolerance is retained during somatic hypermutation in germinal centers is incompletely understood. Two studies now show that Foxp3+ regulatory T cells undergo functional specialization to limit the magnitude of the germinal center response, and they may contribute to our understanding of how germinal center–mediated autoimmunity is prevented (pages 975–982 and 983–988).
nature.com