Inflammation and the balance of Treg and Th17 cells in transplant rejection and tolerance
D Hanidziar, M Koulmanda - Current opinion in organ …, 2010 - journals.lww.com
D Hanidziar, M Koulmanda
Current opinion in organ transplantation, 2010•journals.lww.comBalance of graft-protective regulatory and graft-destructive effector T cells largely depends
on the balance of proinflammatory and anti-inflammatory cytokines in the milieu, in which
donor-directed T-cell response occurs. In the absence of proinflammatory cytokines, the
constitutive expression of TGF-β may guide recipient T cells into a tissue-protective, pro-
tolerant mode. Therefore, targeting adverse tissue inflammation may represent a powerful
means to tilt antidonor immunity towards tolerance.
on the balance of proinflammatory and anti-inflammatory cytokines in the milieu, in which
donor-directed T-cell response occurs. In the absence of proinflammatory cytokines, the
constitutive expression of TGF-β may guide recipient T cells into a tissue-protective, pro-
tolerant mode. Therefore, targeting adverse tissue inflammation may represent a powerful
means to tilt antidonor immunity towards tolerance.
Summary
Balance of graft-protective regulatory and graft-destructive effector T cells largely depends on the balance of proinflammatory and anti-inflammatory cytokines in the milieu, in which donor-directed T-cell response occurs. In the absence of proinflammatory cytokines, the constitutive expression of TGF-β may guide recipient T cells into a tissue-protective, pro-tolerant mode. Therefore, targeting adverse tissue inflammation may represent a powerful means to tilt antidonor immunity towards tolerance.
Lippincott Williams & Wilkins