Endothelial nitric oxide (NO) and its pathophysiologic regulation
A Chatterjee, JD Catravas - Vascular pharmacology, 2008 - Elsevier
Nitric oxide (NO) is a gaseous lipophilic free radical generated by three distinct isoforms of
nitric oxide synthases (NOS), type 1 or neuronal (nNOS), type 2 or inducible (iNOS) and type
3 or endothelial NOS (eNOS). Expression of eNOS is altered in many types of
cardiovascular disease, such as atherosclerosis, diabetes and hypertension. The ubiquitous
chaperone heat shock protein 90 (hsp90) associates with NOS and is important for its proper
folding and function. Current studies point toward a therapeutic potential by modulating …
nitric oxide synthases (NOS), type 1 or neuronal (nNOS), type 2 or inducible (iNOS) and type
3 or endothelial NOS (eNOS). Expression of eNOS is altered in many types of
cardiovascular disease, such as atherosclerosis, diabetes and hypertension. The ubiquitous
chaperone heat shock protein 90 (hsp90) associates with NOS and is important for its proper
folding and function. Current studies point toward a therapeutic potential by modulating …
