[HTML][HTML] Multiple ligands of von Willebrand factor-binding protein (vWbp) promote Staphylococcus aureus clot formation in human plasma
L Thomer, O Schneewind, D Missiakas - Journal of biological chemistry, 2013 - ASBMB
Staphylococcus aureus secretes coagulase (Coa) and von Willebrand factor-binding protein
(vWbp) to activate host prothrombin and form fibrin cables, thereby promoting the
establishment of infectious lesions. The D1-D2 domains of Coa and vWbp associate with,
and non-proteolytically activate prothrombin. Moreover, Coa encompasses C-terminal
tandem repeats for binding to fibrinogen, whereas vWbp has been reported to associate with
von Willebrand factor and fibrinogen. Here we used affinity chromatography with non …
(vWbp) to activate host prothrombin and form fibrin cables, thereby promoting the
establishment of infectious lesions. The D1-D2 domains of Coa and vWbp associate with,
and non-proteolytically activate prothrombin. Moreover, Coa encompasses C-terminal
tandem repeats for binding to fibrinogen, whereas vWbp has been reported to associate with
von Willebrand factor and fibrinogen. Here we used affinity chromatography with non …
