Up-regulation of IL-1 receptor through PI3K/Akt is essential for the induction of iNOS gene expression in hepatocytes
S Teshima, H Nakanishi, M Nishizawa, K Kitagawa… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: Nuclear translocation and DNA binding of NF-κB is essential, as
interleukin-1β (IL-1β) stimulates the induction of inducible nitric oxide synthase (iNOS) gene
expression in hepatocytes. However, recent evidence indicates that the activation of NF-κB
is not sufficient to induce the NF-κB-dependent transcription, and the existence of a second
signaling is postulated. METHODS: Primary cultured hepatocytes were treated with IL-1β,
and the expression of iNOS and type 1 IL-1 receptor (IL-1R1) was analyzed in the presence …
interleukin-1β (IL-1β) stimulates the induction of inducible nitric oxide synthase (iNOS) gene
expression in hepatocytes. However, recent evidence indicates that the activation of NF-κB
is not sufficient to induce the NF-κB-dependent transcription, and the existence of a second
signaling is postulated. METHODS: Primary cultured hepatocytes were treated with IL-1β,
and the expression of iNOS and type 1 IL-1 receptor (IL-1R1) was analyzed in the presence …