The PI3K/AKT pathway and renal cell carcinoma
H Guo, P German, S Bai, S Barnes, W Guo, X Qi… - Journal of genetics and …, 2015 - Elsevier
The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more
pathway components and in more tumor types than any other growth factor signaling
pathway, and thus is frequently activated as a cancer driver. More importantly, the PI3K/AKT
pathway is composed of multiple bifurcating and converging kinase cascades, providing
many potential targets for cancer therapy. Renal cell carcinoma (RCC) is a high-risk and
high-mortality cancer that is notoriously resistant to traditional chemotherapies or …
pathway components and in more tumor types than any other growth factor signaling
pathway, and thus is frequently activated as a cancer driver. More importantly, the PI3K/AKT
pathway is composed of multiple bifurcating and converging kinase cascades, providing
many potential targets for cancer therapy. Renal cell carcinoma (RCC) is a high-risk and
high-mortality cancer that is notoriously resistant to traditional chemotherapies or …