[HTML][HTML] Experience with cultured thymus tissue in 105 children
ML Markert, SE Gupton, EA McCarthy - Journal of Allergy and Clinical …, 2022 - Elsevier
Background Currently, there are no approved therapies to treat congenital athymia, a
condition of immune deficiency resulting in high early mortality due to infection and immune
dysregulation. Multiple syndromic conditions, such as complete DiGeorge syndrome, 22q11.
2 deletion syndrome, CHARGE (coloboma, heart defects, choanal atresia, growth or mental
retardation, genital hypoplasia, and ear anomalies and/or deafness) syndrome, diabetic
embryopathy, other genetic variants, and FOXN1 deficiency, are associated with congenital …
condition of immune deficiency resulting in high early mortality due to infection and immune
dysregulation. Multiple syndromic conditions, such as complete DiGeorge syndrome, 22q11.
2 deletion syndrome, CHARGE (coloboma, heart defects, choanal atresia, growth or mental
retardation, genital hypoplasia, and ear anomalies and/or deafness) syndrome, diabetic
embryopathy, other genetic variants, and FOXN1 deficiency, are associated with congenital …