Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation

WJ Duan, L Liang, MH Pan, DH Lu, TM Wang, SB Li… - Phytomedicine, 2020 - Elsevier
Background Oxidative damage of dopaminergic neurons is the fundamental causes of
Parkinson's disease (PD) that has no standard cure at present. Theacrine, a purine alkaloid
from Chinese tea Kucha, has been speculated to benefit the neurodegeneration in PD,
through similar actions to its chemical analogue caffeine, albeit excluding side effects.
Theacrine has nowadays gained a lot of interest for its multiple benefits, while the
investigations are weak and insufficient. Hypothesis/Purpose It is well-known that tea has a …