Alternative splice variants of the human PD-1 gene
C Nielsen, L Ohm-Laursen, T Barington, S Husby… - Cellular …, 2005 - Elsevier
PD-1 is an immunoregulatory receptor expressed on the surface of activated T cells, B cells,
and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Δex2,
PD-1Δex3, PD-1Δex2, 3, and PD-1Δex2, 3, 4) in addition to the full length isoform. PD-
1Δex2 and PD-1Δex3 are generated by alternative splicing where exon 2 (extracellular IgV-
like domain) and exon 3 (transmembrane domain) respectively are spliced out. PD-1Δex3 is
therefore likely to encode a soluble form of PD-1. PD-1Δex2, 3 lacks exon 2 and 3. These …
and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Δex2,
PD-1Δex3, PD-1Δex2, 3, and PD-1Δex2, 3, 4) in addition to the full length isoform. PD-
1Δex2 and PD-1Δex3 are generated by alternative splicing where exon 2 (extracellular IgV-
like domain) and exon 3 (transmembrane domain) respectively are spliced out. PD-1Δex3 is
therefore likely to encode a soluble form of PD-1. PD-1Δex2, 3 lacks exon 2 and 3. These …
